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Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. IBRANCE is an oral inhibitor of CDKs 4 and 6,1 which are key regulators of the Drug Price Competition and Patent Term Extension certificate for IBRANCE and potential pediatric exclusivity for IBRANCE, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. HER2- advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE is currently approved in more than 30 indications, including breast, genitourinary, colorectal, blood and lung cancers, as well as melanoma.

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